Evidence for structurally different attached states of myosin cross-bridges on actin during contraction of fish muscle.

@article{Harford1992EvidenceFS,
  title={Evidence for structurally different attached states of myosin cross-bridges on actin during contraction of fish muscle.},
  author={Jeffrey J. Harford and John M. Squire},
  journal={Biophysical journal},
  year={1992},
  volume={63 2},
  pages={387-96}
}
Using data from fast time-resolved x-ray diffraction experiments on the synchrotrons at Daresbury and (Deutsches Elektronen Synchrotron [DESY]), it is shown that during contraction of fish muscle there are at least two distinct configurations of myosin cross-bridges on actin, that they appear to have different tension producing properties and that they probably differ in the axial tilt of the cross-bridges on actin. Evidence is presented for newly observed myosin-based layer lines in patterns… CONTINUE READING

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