Evidence for stabilizing selection in a eukaryotic enhancer element

  title={Evidence for stabilizing selection in a eukaryotic enhancer element},
  author={Michael Z. Ludwig and Casey M. Bergman and Nipam H. Patel and Martin Kreitman},
Eukaryotic gene expression is mediated by compact cis-regulatory modules, or enhancers, which are bound by specific sets of transcription factors. The combinatorial interaction of these bound transcription factors determines time- and tissue-specific gene activation or repression. The even-skipped stripe 2 element controls the expression of the second transverse stripe of even-skipped messenger RNA in Drosophila melanogaster embryos, and is one of the best characterized eukaryotic enhancers… CONTINUE READING
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Neurobiology of the C . elegans genome

  • R. R. Zwaal, J. E. Mendel, P. W. Sternberg, R. H. A. Plasterk
  • Science
  • 1998

The genetics of caloric restriction in Caenorhabditis elegans

  • K. Nonogaki, A. M. Strack, M. F. Dallman, L. H. Tecott
  • Proc . Natl Acad . Sci . USA
  • 1998

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