Evidence for stabilizing selection in a eukaryotic enhancer element

@article{Ludwig2000EvidenceFS,
  title={Evidence for stabilizing selection in a eukaryotic enhancer element},
  author={Michael Z. Ludwig and Casey M. Bergman and Nipam H. Patel and Martin Kreitman},
  journal={Nature},
  year={2000},
  volume={403},
  pages={564-567}
}
Eukaryotic gene expression is mediated by compact cis-regulatory modules, or enhancers, which are bound by specific sets of transcription factors. The combinatorial interaction of these bound transcription factors determines time- and tissue-specific gene activation or repression. The even-skipped stripe 2 element controls the expression of the second transverse stripe of even-skipped messenger RNA in Drosophila melanogaster embryos, and is one of the best characterized eukaryotic enhancers… CONTINUE READING
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