Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

@article{Hozumi1976EvidenceFS,
  title={Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.},
  author={N. Hozumi and Susumu Tonegawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1976},
  volume={73 10},
  pages={3628-32}
}
A high-molecular-weight DNA from Balb/c mouse early embryo or from MOPC 321 plasmacytoma (a k-chain producer) was digested to completion with Bacillus amyloliquefaciens strain H restriction enzyme (BamH I). The resulting DNA fragments were fractionated according to size in preparative agarose gel electrophoresis. DNA fragments carrying gene sequences coding for the variable or constant region of k chains were detected by hybridization with purified, 125I-labeled, whole MOPC 321 K MRNA and with… CONTINUE READING
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