Evidence for sodium-dependent active urea secretion in the deepest subsegment of the rat inner medullary collecting duct.

@article{Kato1998EvidenceFS,
  title={Evidence for sodium-dependent active urea secretion in the deepest subsegment of the rat inner medullary collecting duct.},
  author={Akihiko Kawaguchil yoshihiro Kato and Jeff M Sands},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 2},
  pages={423-8}
}
Active reabsorption of urea appears in the initial IMCD (IMCD1) of rats fed a low-protein diet. To determine whether active urea transport also occurs in the deepest IMCD subsegment, the IMCD3, we isolated IMCDs from the base (IMCD1), middle (IMCD2), and tip (IMCD3) regions of the inner medulla from rats fed a normal protein diet and water ad libitum. IMCDs were perfused with identical perfusate and bath solutions. A significant rate of net urea secretion was present only in IMCD3s. Replacing… CONTINUE READING

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