Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney.

@article{Soars2001EvidenceFS,
  title={Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney.},
  author={Matthew G. Soars and Rob Riley and Kirk A. Findlay and Marcus J. Coffey and Brian Burchell},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2001},
  volume={29 2},
  pages={121-6}
}
The in vitro glucuronidation of a range of structurally diverse chemicals has been studied in hepatic and renal microsomes from human donors and the beagle dog. These studies were undertaken to improve on the limited knowledge of glucuronidation by the dog and to assess its suitability as a model species for pharmacokinetic studies. In general, the compounds studied were glucuronidated severalfold more rapidly (based on intrinsic clearance estimates) by DLM than by HLM. Intrinsic clearance… CONTINUE READING
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