Evidence for short-patch mismatch repair in Saccharomyces cerevisiae.

  title={Evidence for short-patch mismatch repair in Saccharomyces cerevisiae.},
  author={E Co{\"i}c and Laurence Gluck and Francis Fabre},
  journal={The EMBO journal},
  volume={19 13},
Recombination events between non-identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well-characterized long-patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short-patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long-patch repair… CONTINUE READING