Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line

@article{Ilkan2017EvidenceFS,
  title={Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line},
  author={Zeki Ilkan and J. R. Wright and A. Goodall and J. Gibbins and C. Jones and M. Mahaut-Smith},
  journal={The Journal of Biological Chemistry},
  year={2017},
  volume={292},
  pages={9204 - 9217}
}
  • Zeki Ilkan, J. R. Wright, +3 authors M. Mahaut-Smith
  • Published 2017
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. We therefore sought to investigate the expression and functional relevance of MS channels in human platelets. The effect of shear stress on Ca2+ entry in human platelets and Meg-01 megakaryocytic cells loaded with Fluo-3 was examined by confocal microscopy. Cells were attached to glass coverslips within flow… CONTINUE READING
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    References

    SHOWING 1-10 OF 75 REFERENCES
    Calcium signaling in platelets
    • 314
    Calcium‐activated potassium channels in human platelets.
    • 44
    The unique contribution of ion channels to platelet and megakaryocyte function
    • M. Mahaut-Smith
    • Chemistry, Medicine
    • Journal of thrombosis and haemostasis : JTH
    • 2012
    • 38
    Piezo1 integration of vascular architecture with physiological force
    • 410
    • PDF
    Patch-clamp recordings of electrophysiological events in the platelet and megakaryocyte.
    • 17