Corpus ID: 12837912

Evidence for separate carriers for purine nucleosides and for pyrimidine nucleosides in the renal brush border membrane.

@article{Hir1990EvidenceFS,
  title={Evidence for separate carriers for purine nucleosides and for pyrimidine nucleosides in the renal brush border membrane.},
  author={M. Le Hir},
  journal={Renal physiology and biochemistry},
  year={1990},
  volume={13 3},
  pages={
          154-61
        }
}
  • M. Le Hir
  • Published 1990
  • Medicine
  • Renal physiology and biochemistry
The aim of the present study was to test if the transport of all nucleosides in rat renal brush border membranes occurs via a common carrier or if specific carriers exist for various groups of nucleosides. We measured the inward transport of radiolabeled nucleosides into brush border vesicles. The effect of unlabeled nucleosides present inside of the vesicles (trans-stimulation) or outside of the vesicles (cis-inhibition) was studied. Uphill influx of a nucleoside into the vesicles could be… Expand
2 Citations
Intestinal Uptake of Uridine in Suckling Rats: Mechanism and Ontogeny
  • E. McCloud, R. Mathis, K. Grant, H. Said
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1994
Functional disruption of pyrimidine nucleoside transporter CNT1 results in a novel inborn error of metabolism with high excretion of uridine and cytidine