Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: studies in M54 mu-transgenic mice.

Abstract

Serum monoclonal immunoglobulins (M-Ig) appear during aging but little is known about the immunological factors which lead to their development. We have investigated whether such M-Ig occur as a clonally random process or result from V-region-directed selective pressures. We have analyzed a mu-transgenic mouse strain in which over 95% of all splenic B cells… (More)

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Cite this paper

@article{Gueret1993EvidenceFS, title={Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: studies in M54 mu-transgenic mice.}, author={Renaud M Gueret and Alf Grandien and J. Sebastian Andersson and A C O Coutinho and James N Radl and Marcelo Weksler}, journal={European journal of immunology}, year={1993}, volume={23 7}, pages={1735-8} }