Evidence for rolling circle replication of tandem genes in Drosophila

  title={Evidence for rolling circle replication of tandem genes in Drosophila},
  author={Sarit Cohen and Neta Agmon and Keren Yacobi and Margarita Mislovati and Daniel Segal},
  journal={Nucleic Acids Research},
  pages={4519 - 4526}
Extrachromosomal circular DNA (eccDNA) is one characteristic of the plasticity of the eukaryotic genome. It is found in various organisms and contains sequences derived primarily from repetitive chromosomal DNA. Using 2D gel electrophoresis, we have previously detected eccDNA composed of chromosomal tandem repeats throughout the life cycle of Drosophila. Here, we report for the first time evidence suggesting the occurrence of rolling circle replication of eccDNA in Drosophila. We show, on 2D… CONTINUE READING
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