Evidence for restricted diversity of antigen-specific human antibodies in immunized hu-PBL-SCID mice.

@article{Bazin1996EvidenceFR,
  title={Evidence for restricted diversity of antigen-specific human antibodies in immunized hu-PBL-SCID mice.},
  author={Richard Bazin and M C Chevrier and R{\'e}mi Delage and R Lemieux},
  journal={Human antibodies and hybridomas},
  year={1996},
  volume={7 3},
  pages={
          129-34
        }
}
Previous studies have revealed that specific human humoral immune responses could be produced in immunized SCID mice after engraftment of human lymphocytes (hu-PBL-SCID). On the other hand, the engrafted repertoire of B cell clones is known to be skewed in hu-PBL-SCID with the corresponding production of only a limited set of major human antibodies. In this work, we have analyzed the diversity of tetanus toxoid-specific human antibodies produced in immunized hu-PBL-SCID mice in comparison with… CONTINUE READING