Evidence for renal ischaemia as a cause of mercuric chloride nephrotoxicity

The present study was undertaken to investigate if the source of oxidative stress and the renal injury produced by mercuric chloride could be renal ischaemia. Verapamil Vp was used because it was described that calcium channel blockers protect cells from nephrotoxicants and from ischaemia. Vp (75 μg/kg, i.v.; 30 min before HgCl2 injection) prevented… CONTINUE READING