Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones

@inproceedings{Shanley2010EvidenceFR,
  title={Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones},
  author={Lynne J. Shanley and Marissa Lear and Scott Davidson and Ruth A. Ross and Alasdair Mackenzie},
  booktitle={Journal of Neuroinflammation},
  year={2010}
}
The neuropeptide substance-P (SP) is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic inflammation. The promoter of TAC1 (TAC1prom) plays a central role in the regulation of the TAC1 gene but requires the presence of a second regulatory element; ECR2, to support TAC1 expression in sensory neurones and to respond appropriately to signalling pathways such as MAPkinases and noxious induction by capsaicin. We examined whether the effect of capsaicin on… CONTINUE READING

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