Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors
@article{Chaperon2003EvidenceFR, title={Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors}, author={Fr{\'e}d{\'e}rique Chaperon and Mark David Tricklebank and Liliane Unger and Hans Ch Neijt}, journal={Neuropharmacology}, year={2003}, volume={44}, pages={1047-1053} }
59 Citations
Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test
- Biology, PsychologyNeuropsychopharmacology
- 2005
The pharmacological selectivity of the compounds tested suggests that the antidepressant-like effects of quinpirole are most likely mediated mainly by D2 and to a lesser extent by D3 but not D4 receptors.
Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
- ChemistryJournal of Pharmacology and Experimental Therapeutics
- 2005
It is reported that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve.
Evidence for thermoregulation by dopamine D1 and D2 receptors in the anteroventral preoptic region during normoxia and hypoxia
- Biology, PsychologyBrain Research
- 2004
Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine D3 and D2 receptor sensitivity
- Biology, PsychologyPsychopharmacology
- 2010
These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of D3 and D2 receptors, with enhancements ofD3-mediated behavioral effects observed within 72 h and enhancements of D2- mediated behavioral effects apparent 42 days after cocaine.
The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
- Biology, PsychologyBrain Research Reviews
- 2005
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
- Biology, PsychologyPsychopharmacology
- 2007
D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors.
Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats
- Biology, PsychologyJournal of Pharmacology and Experimental Therapeutics
- 2010
Feeding conditions affecting the behavioral effects of direct-acting DA receptor agonists might also have an impact on the effects of indirect-acting agonists such as cocaine and amphetamine.
Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925.
- Biology, MedicineThe international journal of neuropsychopharmacology
- 2010
It is demonstrated that [11C](+)-PHNO binding can be blocked by a D3 receptor antagonist and confirmed preclinical findings that the signal in the substantia nigra and globus pallidus is mainly reflective of its binding to D3 receptors.
Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition.
- Biology, PsychologyEuropean journal of pharmacology
- 2014
Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats
- BiologyBehavioural pharmacology
- 2017
The results suggest that TAar1 agonists may interact with D3 receptors and/or its downstream pathways, as opposed to D2 receptors, which may shed light on a previously unexplored possibility for the mechanism of TAAR1-mediated effects.
References
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It is shown that S 14297 is a full and partial agonist at D3R and D2R, respectively, and the results suggest that hypothermia does not result from a selective stimulation of the D 3R.
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Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice
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Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
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