Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors

@article{Chaperon2003EvidenceFR,
  title={Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors},
  author={Fr{\'e}d{\'e}rique Chaperon and Mark David Tricklebank and Liliane Unger and Hans Ch Neijt},
  journal={Neuropharmacology},
  year={2003},
  volume={44},
  pages={1047-1053}
}
Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test
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Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
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Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
TLDR
D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors.
Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats
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Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925.
TLDR
It is demonstrated that [11C](+)-PHNO binding can be blocked by a D3 receptor antagonist and confirmed preclinical findings that the signal in the substantia nigra and globus pallidus is mainly reflective of its binding to D3 receptors.
Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats
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The results suggest that TAar1 agonists may interact with D3 receptors and/or its downstream pathways, as opposed to D2 receptors, which may shed light on a previously unexplored possibility for the mechanism of TAAR1-mediated effects.
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References

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Role of dopamine D3 receptors in thermoregulation: a reappraisal
TLDR
It is shown that S 14297 is a full and partial agonist at D3R and D2R, respectively, and the results suggest that hypothermia does not result from a selective stimulation of the D 3R.
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
TLDR
Data demonstrate that the novel naphthofurane, (+)-S 14297, is a selective ligand (antagonist) at dopamine D3 receptors and suggest that their activation mediates hypothermia in the rat.
Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors?
TLDR
The findings suggest that the hypothermia and PPI disruptions seen with some of these dopamine agonists may be mediated by central D3 receptors; however, only studies using more selective dopamine receptor ligands can definitively rule out effects at the D2 or D4 receptors.
S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
TLDR
D(2)-receptors are principally involved in these paradigms, although D(3)-receptionors may contribute to induction of hypothermia and PEs, and S33084 was inactive in models of potential antipsychotic and extrapyramidal activity and failed to modify spontaneous locomotor behavior.
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