Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors

@article{Chaperon2003EvidenceFR,
  title={Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors},
  author={Fr{\'e}d{\'e}rique Chaperon and Mark David Tricklebank and Liliane Unger and Hans Ch Neijt},
  journal={Neuropharmacology},
  year={2003},
  volume={44},
  pages={1047-1053}
}
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59 Citations
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35
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3
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59 Citations

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Citation Type

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It is reported that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve.
Evidence for thermoregulation by dopamine D1 and D2 receptors in the anteroventral preoptic region during normoxia and hypoxia
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These studies suggest that temporal differences exist in the development of cocaine-induced sensitization of D3 and D2 receptors, with enhancements ofD3-mediated behavioral effects observed within 72 h and enhancements of D2- mediated behavioral effects apparent 42 days after cocaine.
The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
TLDR
D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors.
Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats
TLDR
Feeding conditions affecting the behavioral effects of direct-acting DA receptor agonists might also have an impact on the effects of indirect-acting agonists such as cocaine and amphetamine.
Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925.
TLDR
It is demonstrated that [11C](+)-PHNO binding can be blocked by a D3 receptor antagonist and confirmed preclinical findings that the signal in the substantia nigra and globus pallidus is mainly reflective of its binding to D3 receptors.
Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition.
Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats
TLDR
The results suggest that TAar1 agonists may interact with D3 receptors and/or its downstream pathways, as opposed to D2 receptors, which may shed light on a previously unexplored possibility for the mechanism of TAAR1-mediated effects.
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References

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Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists
Role of dopamine D3 receptors in thermoregulation: a reappraisal
TLDR
It is shown that S 14297 is a full and partial agonist at D3R and D2R, respectively, and the results suggest that hypothermia does not result from a selective stimulation of the D 3R.
Independent roles of dopamine D1 and D2/3 receptors in rat thermoregulation
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Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice
Evidence for specific involvement of dopamine D1 and D2 receptors in the regulation of body temperature in the rat.
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
TLDR
Data demonstrate that the novel naphthofurane, (+)-S 14297, is a selective ligand (antagonist) at dopamine D3 receptors and suggest that their activation mediates hypothermia in the rat.
Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors?
TLDR
The findings suggest that the hypothermia and PPI disruptions seen with some of these dopamine agonists may be mediated by central D3 receptors; however, only studies using more selective dopamine receptor ligands can definitively rule out effects at the D2 or D4 receptors.
Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors
Hypothermic Effects of Dopamine D3 Receptor Agonists in the Island of Calleja Magna. Potentiation by D1 Activation
S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
TLDR
D(2)-receptors are principally involved in these paradigms, although D(3)-receptionors may contribute to induction of hypothermia and PEs, and S33084 was inactive in models of potential antipsychotic and extrapyramidal activity and failed to modify spontaneous locomotor behavior.
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