Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex.

Abstract

Cognitive functions that require the prefrontal cortex are highly sensitive to aging in humans, nonhuman primates, and rodents, although the neurobiological correlates of this vulnerability remain largely unknown. It has been proposed that dendritic spines represent the primary site of structural plasticity in the adult brain, and recent data have supported… (More)
DOI: 10.1523/JNEUROSCI.0839-11.2011

Topics

6 Figures and Tables

Cite this paper

@article{Bloss2011EvidenceFR, title={Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex.}, author={Erik B. Bloss and William G. M. Janssen and Daniel T Ohm and Frank J. Yuk and Shannon Wadsworth and Karl M Saardi and Bruce S. McEwen and John H. Morrison}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2011}, volume={31 21}, pages={7831-9} }