Evidence for reduced copying fidelity of DNA polymerases α, δ, and ε from Novikoff hepatoma cells

@article{Fox1997EvidenceFR,
  title={Evidence for reduced copying fidelity of DNA polymerases α, δ, and ε from Novikoff hepatoma cells},
  author={Gabriele Fox and Odilia Popanda and Heinz Walter Thielmann},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1997},
  volume={123},
  pages={659-668}
}
 To investigate whether or not DNA polymerases α, δ, and ε from tumor cells have acquired properties that might be responsible for mutations found in tumor development, we investigated copying fidelities of DNA polymerases α, δ, and ε from the highly malignant Novikoff hepatoma cells and compared them to the corresponding enzymes from normal rat liver. DNA… CONTINUE READING