Evidence for reduced accumulation of exogenous neurotrophin by aged sympathetic neurons.

@article{Kudwa2002EvidenceFR,
  title={Evidence for reduced accumulation of exogenous neurotrophin by aged sympathetic neurons.},
  author={Andrea E. Kudwa and Sarah E. Shoemaker and Keith A. Crutcher and Lori G Isaacson},
  journal={Brain research},
  year={2002},
  volume={948 1-2},
  pages={24-32}
}
The present study investigated the potential for neurotrophin uptake by cerebrovascular axons and subsequent accumulation in the aged superior cervical ganglion (SCG) following a two week intracerebroventricular infusion of nerve growth factor (NGF). In the SCG from aged rats, NGF protein levels declined significantly compared with the SCG from young adult rats. Following NGF infusion, perivascular axons from both young adult and aged rats showed intense NGF immunostaining. In addition… CONTINUE READING