Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro.

@article{Masuyama1992EvidenceFR,
  title={Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro.},
  author={Jun-ichi Masuyama and Jeffrey S. Berman and William W. Cruikshank and Chikao Morimoto and David M. Center},
  journal={Journal of immunology},
  year={1992},
  volume={148 5},
  pages={1367-74}
}
As T cells actively extravasate from blood, they adhere to endothelium and then migrate out of the vessel with a locomotive activity. Although both adhesion and locomotion are properties associated with activated T cells, the two processes are not necessarily associated with identical activation states. Using human endothelial cells (EC) cultured to confluence on collagen gel, we examined the activation state of human peripheral blood T cells that adhere to and migrate through EC monolayers… CONTINUE READING
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