Evidence for protein phosphatase inhibitor‐1 playing an amplifier role in β‐adrenergic signaling in cardiac myocytes
@article{ElArmouche2003EvidenceFP, title={Evidence for protein phosphatase inhibitor‐1 playing an amplifier role in $\beta$‐adrenergic signaling in cardiac myocytes}, author={Ali El-Armouche and Thomas Rau and Oliver Zolk and Diana Ditz and Torsten Pamminger and Wolfram-Hubertus Zimmermann and Elmar J{\"a}ckel and Sian E. Harding and Peter Bokník and Joachim Neumann and Thomas Eschenhagen}, journal={The FASEB Journal}, year={2003}, volume={17} }
The protein phosphatase inhibitor‐1 (PPI‐1) inhibits phosphatase type‐1 (PP1) only when phosphorylated by protein kinase A and could play a pivotal role in the phosphorylation/dephosphorylation balance. Rat cardiac PPI‐1 was cloned by reverse transcriptase‐polymerase chain reaction, expressed in Eschericia coli, evaluated in phosphatase assays, and used to generate an antiserum. An adenovirus was constructed encoding PPI‐1 and green fluorescent protein (GFP) under separate cytomegalovirus…
121 Citations
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