Evidence for protein phosphatase inhibitor‐1 playing an amplifier role in β‐adrenergic signaling in cardiac myocytes

@article{ElArmouche2003EvidenceFP,
  title={Evidence for protein phosphatase inhibitor‐1 playing an amplifier role in β‐adrenergic signaling in cardiac myocytes},
  author={A. El-Armouche and T. Rau and O. Zolk and D. Ditz and T. Pamminger and W. Zimmermann and E. J{\"a}ckel and S. Harding and P. Bokn{\'i}k and J. Neumann and T. Eschenhagen},
  journal={The FASEB Journal},
  year={2003},
  volume={17}
}
The protein phosphatase inhibitor‐1 (PPI‐1) inhibits phosphatase type‐1 (PP1) only when phosphorylated by protein kinase A and could play a pivotal role in the phosphorylation/dephosphorylation balance. Rat cardiac PPI‐1 was cloned by reverse transcriptase‐polymerase chain reaction, expressed in Eschericia coli, evaluated in phosphatase assays, and used to generate an antiserum. An adenovirus was constructed encoding PPI‐1 and green fluorescent protein (GFP) under separate cytomegalovirus… Expand
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