Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea.

@article{Patel1995EvidenceFP,
  title={Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea.},
  author={Hema J. Patel and Peter J Barnes and Tomoe Takahashi and Samad Tadjkarimi and Magdi Habib Yacoub and Maria G Belvisi},
  journal={American journal of respiratory and critical care medicine},
  year={1995},
  volume={152 3},
  pages={872-8}
}
Functional studies suggest the presence of prejunctional muscarinic autoreceptors on cholinergic nerves in human airways. However, these studies are an indirect method of evaluating changes in neurally evoked acetylcholine (ACh) release. We have investigated the presence of muscarinic autoreceptors in human and guinea pig trachea by comparing the effects of the muscarinic receptor antagonists pirenzepine (M1), methoctramine (M2), 4-DAMP (M3), and rispenzepine (M1/M3) on cholinergic neural… CONTINUE READING