Evidence for potential functionality of nuclearly-encoded humanin isoforms.

  title={Evidence for potential functionality of nuclearly-encoded humanin isoforms.},
  author={Marek Bodzioch and Katarzyna Lapicka-Bodzioch and Barbara Zapala and Wojciech Kamysz and Beata Kie{\'c}-Wilk and Aldona Dembinska-Kiec},
  volume={94 4},
Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. We provide bioinformatic and expression data suggesting the existence of 13 MT-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides. At least ten of these nuclear genes are expressed in human tissues, and respond to staurosporine (STS) and beta-carotene. Sequence comparisons of the nuclear HN… CONTINUE READING
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