Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis

@article{Tyner1986EvidenceFP,
  title={Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis},
  author={Angela L. Tyner and Elaine Fuchs},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={103},
  pages={1945 - 1955}
}
Keratin K6 is a protein that is expressed in human skin under conditions of hyperproliferation (e.g., wound-healing, psoriasis, and cell culture) and malignant transformation (e.g., squamous cell carcinomas). When induced, the appearance of K6 is rapid: if skin tissue is placed in radiolabeled culture medium, this protein can be detected within an hour. The regulation of K6 seems to be controlled partly by a posttranscriptional mechanism: At least two K6 genes are actively transcribed both in… CONTINUE READING

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