Corpus ID: 43834074

Evidence for possible interrelationship between gluconeogenesis and ketogenesis?

  title={Evidence for possible interrelationship between gluconeogenesis and ketogenesis?},
  author={L. K{\"u}mmel},
  journal={Biochemistry international},
  volume={8 3},
  • L. Kümmel
  • Published 1984
  • Chemistry, Medicine
  • Biochemistry international
Effects of ketogenic substrates on gluconeogenesis by rat hepatocytes were examined. D,L-3-Hydroxybutyrate (5 mM) stimulated gluconeogesis from lactate by 41%, the effect being the same as that of 5 mM acetate (43%). Acetoacetate up to 40 mM had no stimulating effect; conversely, it partially or completely abolished the observed stimulating effects of acetate, 3-hydroxybutyrate, or oleate. 3-Hydroxybutyrate also stimulated gluconeogenesis from serine by 70%, the effect being much higher than… Expand
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