Evidence for positive and negative regulation of the Hox-3.1 gene.

  title={Evidence for positive and negative regulation of the Hox-3.1 gene.},
  author={Charles J Bieberich and Manuel F. Utset and Alexander Awgulewitsch and Frank H. Ruddle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 21},
The region-specific patterns of expression of mouse homeobox genes are considered important for establishing the embryonic body plan. A 5-kilobase (kb) DNA fragment from the Hox-3.1 locus that is sufficient to confer region-specific expression to a beta-galactosidase reporter gene in transgenic mouse embryos has been defined. The observed reporter gene expression pattern closely parallels endogenous Hox-3.1 expression in 8- to 9.5-day postcoitum (p.c.) embryos. At 10.5 days p.c. and later, the… CONTINUE READING

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