Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in dictyostelium

@article{Early1995EvidenceFP,
  title={Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in dictyostelium},
  author={Andrew Early and Tomoaki Abe and Jeffrey G. Williams},
  journal={Cell},
  year={1995},
  volume={83},
  pages={91-99}
}
We present evidence that Dictyostelium slug tip cells, the pstA cells, may arise by positional differentiation, but at a site remote from that which they will eventually occupy. When first detectable, the pstA cells form a peripheral ring surrounding the other prestalk cell subtype, the pstO cells, but subsequently move above the pstO cells to form the tip. Because pstA cell differentiation requires a 10-fold higher concentration of differentiation-inducing factor, the stalk cell inducer, the… CONTINUE READING
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