Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.

@article{Lindsberg1990EvidenceFP,
  title={Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.},
  author={Perttu J Lindsberg and Tian-li Yue and Kai U. Frerichs and John M. Hallenbeck and G{\"u}nter Feuerstein},
  journal={Stroke},
  year={1990},
  volume={21 10},
  pages={1452-7}
}
Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment with antagonists of platelet-activating factor, no study has proved endogenous production of platelet-activating factor in ischemia of the central nervous system. We hypothesized that endogenous production of platelet-activating factor participates in the early pathologic… CONTINUE READING
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Effect of systemic PAF-acether on the spinal cord microcirculation

  • PJ Lindsberg, IA Paakkari, JM Hallenbeck, G Feuerstein
  • / Lipid Mediators
  • 1990
6 Excerpts

Platelet-activating factor antagonist protective in progressive focal brain injury

  • KU Frerichs, PJ Lindsberg, JM Hallenbeck, GZ Feuerstein
  • Stroke
  • 1990
1 Excerpt

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