Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease.

@article{Chandrasekaran1996EvidenceFP,
  title={Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease.},
  author={Krish Chandrasekaran and K Hatanp{\"a}{\"a} and Donald R. Brady and Stanley I. Rapoport},
  journal={Experimental neurology},
  year={1996},
  volume={142 1},
  pages={80-8}
}
In vivo imaging of patients with Alzheimer's disease using positron emission tomography (PET) demonstrates progressive reductions in brain glucose metabolism and blood flow in relation to dementia severity, more so in association than primary cortical regions. These reductions likely follow regional synaptic loss or dysfunction and reflect physiological down-regulation of gene expression for glucose delivery, oxidative phosphorylation (OXPHOS), and energy consumption in brain. Indeed, the… CONTINUE READING