Evidence for physical interaction between the immunoglobulin heavy chain variable region and the 3' regulatory region.

@article{Ju2007EvidenceFP,
  title={Evidence for physical interaction between the immunoglobulin heavy chain variable region and the 3' regulatory region.},
  author={Zhongliang Ju and Sabrina Angela Volpi and Rabih Hassan and Nancy Leticia Hern{\'a}ndez Mart{\'i}nez and Sandra L. Giannini and Tamar Gold and Barbara K. Birshtein},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={
          35169-78
        }
}
B cell-specific expression of immunoglobulin heavy chain (IgH) genes utilizes two cis regulatory regions, the intronic enhancer (Emicro), located in the J(H)-Cmicro intron, and a complex regulatory region that lies 3' to the IgH gene cluster, 3' RR. We hypothesized that the 3' RR is involved in IgH gene transcription in plasma cells via physical interaction between distal 3' RR enhancers and target V(H) sequences, with loop formation by intervening DNA. In support of this hypothesis we report… CONTINUE READING

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