Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors.

@article{Filippova1999EvidenceFP,
  title={Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors.},
  author={Natalia Valerevna Filippova and Ricky Dudley and David S Weiss},
  journal={The Journal of physiology},
  year={1999},
  volume={518 ( Pt 2)},
  pages={
          385-99
        }
}
1. Recombinant wild-type or mutant human rho1 GABA receptors were expressed in human embryonic kidney (HEK) 293 or monkey COS-7 cells and studied using the patch clamp technique. 2. Standard whole-cell recordings with 4 mM Mg-ATP in the patch pipette induced a time-dependent decrease in the GABA-activated current (IGABA) amplitude that was not the result of a decrease in GABA sensitivity. In contrast, IGABA remained stable when recordings were obtained using the perforated patch configuration… CONTINUE READING
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