Evidence for parent of origin effect in late-onset Alzheimer disease.

  title={Evidence for parent of origin effect in late-onset Alzheimer disease.},
  author={Susan Spear Bassett and Dimitrios Avramopoulos and Daniele Fallin},
  journal={American journal of medical genetics},
  volume={114 6},
Evidence for a parent of origin effect in Alzheimer disease was obtained from a sample of 148 sibships on which affection status of the parents was sought using family history interviews. The parent study recruited families with two or more affected sibs for late onset AD utilizing rigorous diagnostic criteria. In 74 families, there was evidence of an affected parent, 49 maternal and 25 paternal. Genome scan data were analyzed for the sample as a whole and for the maternal and paternal families… CONTINUE READING

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