Evidence for parallel development of tolerance to the hyperactivating and discoordinating effects of ethanol

Rats maintained on diets containing 6.5% ethanol or equicaloric sucrose solutions were challenged at weekly intervals with 1.5 or 2.0 g/kg ethanol or isotonic saline 14 h after withdrawal from the diet. Tolerance developed to both the hyperactivating (increased line crossing and time active) and discoordinating (disrupted rotarod performance) effects of the… CONTINUE READING