Evidence for p62 aggregate formation: role in cell survival.

  title={Evidence for p62 aggregate formation: role in cell survival.},
  author={Michael G. Paine and Jeganathan Ramesh Babu and Michael Lamar Seibenhener and Michael Wooten},
  journal={FEBS letters},
  volume={579 22},
The polyubiquitin-binding protein p62 has been shown to localize in aggregates common to several types of diseases. Here, we report that p62 forms independent fibrillar aggregates in vitro in a time- and concentration-dependent manner. FTIR spectra and ThT fluorescence assay of p62 reveals increased beta-sheet content as aggregates form compared to the native protein. The fibrillar nature of the aggregates was observed by transmission electron microscopy. Overexpression of p62 in HEK cells… CONTINUE READING
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