Evidence for nucleosome depletion at active regulatory regions genome-wide

  title={Evidence for nucleosome depletion at active regulatory regions genome-wide},
  author={Cheol-Koo Lee and Yoichiro Shibata and Bhargavi Rao and Brian D. Strahl and Jason D. Lieb},
  journal={Nature Genetics},
The identification of nuclease-hypersensitive sites in an active globin gene and in the 5′ regions of fruit fly heat shock genes first suggested that chromatin changes accompany gene regulation in vivo. Here we present evidence that the basic repeating units of eukaryotic chromatin, nucleosomes, are depleted from active regulatory elements throughout the Saccharomyces cerevisiae genome in vivo. We found that during rapid mitotic growth, the level of nucleosome occupancy is inversely… CONTINUE READING
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