Corpus ID: 17010023

Evidence for nootropic effect of BR-16A (Mentat), a herbal psychotropic preparation, in mice.

@article{Kulkarni1992EvidenceFN,
  title={Evidence for nootropic effect of BR-16A (Mentat), a herbal psychotropic preparation, in mice.},
  author={Shrinivas Krishnarao Kulkarni and Anita Kamra Verma},
  journal={Indian journal of physiology and pharmacology},
  year={1992},
  volume={36 1},
  pages={
          29-34
        }
}
  • S. Kulkarni, A. Verma
  • Published 1992
  • Psychology, Medicine
  • Indian journal of physiology and pharmacology
BR-16A (Mentat 50-500 mg/kg) improved acquisition and retention of a passive avoidance task in a step-down paradigm in mice. BR-16A (50-500 mg/kg) reversed scopolamine (0.3 mg/kg)-induced disruption of acquisition and retention. BR 16-A (50 and 100 mg/kg) attenuated amnesia produced by the acute treatment with electroconvulsive shock (ECS), immediately after training. Chronic treatment with ECS, for 6 successive days at 24 h interval, disrupted memory consolidation on the 7th day. Daily… Expand
Effect of BR-16A (MentatR) on cognitive deficits in aluminium-treated and aged rats
TLDR
It is suggested that BR-16A (Mentat) improves learning and memory in aluminium-treated and aged rats. Expand
Herbal pharmacotherapy for the attenuation of electroconvulsive shock-induced anterograde and retrograde amnestic deficits.
TLDR
It is concluded that BR-16A facilitates learning and that this effect extends to a protection against ECS-induced anterograde and retrograde amnesia, and may hence hold promise in the restriction of ECT-induced cognitive compromise. Expand
BR-16A protects against ECS-induced anterograde amnesia
TLDR
It is concluded that BR-16A facilitates learning, and that this effect extends to a protection against ECS-induced anterograde amnesia and may hold promise in the containment of electroconvulsive therapy (ECT)-induced cognitive compromise. Expand
BR-16A restricts development of electroconvulsive shock-induced retrograde amnesia
TLDR
It is hoped that BR-16A will offer a viable solution to the problem of memory deficits following ECT, as cholinergic facilitation may be involved, as evidenced by the reversal of scopolamine-induced amnesia and it may also influence opioid neurotransmission. Expand
On the sleep promoting effects of BR-16A: interaction with GABAergic modulators.
TLDR
Sleep promoting effect of BR-16A in combination with GABAergic drugs (triazolam and alprazolam) suggested that these drugs have common mechanism in sleep promotingEffect of pentobarbitone and could be used along with other GABAergic hypnotics for the treatment of insomnia. Expand
BR-16 A Enhances Learning in Sprague – Dawley Rats
BR-16A is a herbal (non-allopathic) medication used in India to enhance cognition in this study. Wistar rats (n=24) received either BR-16A (200 mg/kg/day) or vehicle alone for 3 weeks. Over 4Expand
Effect of BR-16A on Alpha-2 Adrenergic, Dopamine Autoreceptor and Dopamine Postsynaptic Receptor Functioning
TLDR
The results suggest that BR-16A does not interfere with alpha-2 adrenergic and dopamine autoreceptor functioning, and that it enhances dopamine postsynaptic receptor activity. Expand
ECT-induced anterograde amnesia: can the deficits be minimized?
TLDR
It is concluded that BR-16A protects against ECS-induced anterograde amnesia and may have scope in minimizing ECT-induced learning deficits. Expand
APPRAISAL OF SCOPOLAMINE-INDUCED ANTIAMNESIC EFFECT OF SPHAERANTHUS INDICUS IN MICE
Summary The effect of Ether extract of Sphaeranthus indicus (SI) was investigated in mice for memory enhancing activity using various experimental paradigms of learning and memory viz. TransferExpand
Learning and Memory Enhancing Effects of BacoLive andreg; (An Enriched Composition of Bacopa monnieri Extract) in Scopolamine Induced Memory Impaired Mice
TLDR
BacoLive® demonstrated learning and memory enhancing effects and reversed memory loss effects induced by scopolamine in mice, which suggest its beneficial role in conditions associated with memory and learning dysfunctions. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 27 REFERENCES
Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice.
  • A. Sharma, S. Kulkarni
  • Chemistry, Medicine
  • Methods and findings in experimental and clinical pharmacology
  • 1990
TLDR
Combined administration of lower dose (+/-)baclofen and subeffective dose of GABA showed significant decrease in latency and number of mistakes in scopolamine-treated animals. Expand
MK‐801 produces antianxiety effect in elevated plus‐maze in mice
The antianxiety effect of the non‐competitive NMDA receptor antagonist, MK‐801, was investigated in the present study in the elevated plus‐maze paradigm in mice. During a 5‐min session of the test,Expand
Scopolamine impairs learning performance of rats in a 14-unit T-maze
TLDR
Cognitive performance deficits observed following scopolamine administration in the present study resembled age-related impairments in rats and mice previously observed in this task. Expand
Utility of an elevated plus-maze for dissociation of amnesic and behavioral effects of drugs in mice.
TLDR
The results suggested that the prolongation of the transfer latency on retention testing in the plus-maze method might be used as an indicator for impairment of learning and memory induced by the drugs which have amnesic properties, and is not related to the change in transferLatencies on training. Expand
Scopolamine effects on memory retention in mice: a model of dementia?
TLDR
The overall results indicate that pretraining administration of scopolamine impairs learning and to some degree memory processing, in addition to some impairment of memory processing. Expand
Differential effects of scopolamine on working and reference memory of rats in the radial maze
TLDR
Results confirm the behavioural similarities between the memorial effects of hippocampectomy and anticholinergics, and implicate cholinergically innervated structures in working memory. Expand
Animal models of Alzheimer's disease: experimental cholinergic denervation
TLDR
Future research should focus upon the systematic production and analysis of non-cholinergic neurotransmitter and cytoskeletal abnormalities to determine the contribution of these factors to the pathology seen in AD and the production of deficit in aged animals, which may more closely approximate the deficits in AD. Expand
Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
TLDR
A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity. Expand
Mentat in Hyperactivity and Attention Deficiency Disorders - A double-blind, placebo-controlled study
Behaviour disorders present a very important problem in paediatric practice. They may be associated with normal physical development and intelligence or may be associated with some degree ofExpand
Management of behaviour disorders and minimal brain dysfunction
Twenty five children, aged between 3-12 years, suffering from mild to moderate degree of behavioural disorders and/or mental deficit were included in the study. They underwent the BinetKamat andExpand
...
1
2
3
...