Evidence for non-linear pharmacokinetics of oxytocin in anesthetizetized rat.

  title={Evidence for non-linear pharmacokinetics of oxytocin in anesthetizetized rat.},
  author={Val{\'e}rie Morin and J{\'e}r{\^o}me R E Del Castillo and Simon Authier and Norma Ybarra and Colombe Otis and Dominique Gauvin and Jolanta Gutkowska and Eric Troncy},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  volume={11 4},
PURPOSE Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. METHODS A single intravenous bolus of OT was given at doses of 200, 300, 500, 1000, 3000, 5000 and 10000 ng/kg to anesthetized male rats (n >= 4 per dose). Blood samples (6) were taken over 72 min to 150 min, depending on dose. The individual time-courses of plasma OT… CONTINUE READING

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