Evidence for muscle-dependent neuromuscular synaptic site determination in mammals.


Recent evidence challenges the prevalent view that neural factors induce the formation of a de novo postsynaptic apparatus during development of the vertebrate neuromuscular junction. The latest experiments suggest an alternative model in which the muscle fiber induces a nascent postsynaptic apparatus and sets the location of the future synapse. On axonal… (More)
DOI: 10.1523/JNEUROSCI.5080-07.2008


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