Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus.

@article{Singh1998EvidenceFM,
  title={Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus.},
  author={Ram Raj Singh and Bevra Hannahs Hahn and Betty P. Tsao and Fanny M. Ebling},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 10},
  pages={1841-9}
}
Individuals with systemic autoantibody-mediated diseases such as lupus have polyclonal T and B cell activation. Yet, autoantibody production is restricted to certain autoantigens. The mechanisms underlying this phenomenon remain unclear. We propose three potential mechanisms by which autoreactive helper T cell responses diversify to become polyclonal, yet are restricted to certain antigens. First, using a model where self-Ig peptides spontaneously activate T cells and modulate disease in lupus… CONTINUE READING
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Reciprocal spontaneous T helper determinant spreading in autoimmune lupus-prone but not in normal strains

  • R. R. Singh, F. M. Ebling, E. E. Sercarz, B. H. Hahn
  • J. Invest. Med. 45:112A
  • 1997

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