Evidence for multiple glucuronide transporters in rat liver microsomes.

@article{Csala2004EvidenceFM,
  title={Evidence for multiple glucuronide transporters in rat liver microsomes.},
  author={Mikl{\'o}s Csala and Adam G. Staines and G{\'a}bor B{\'a}nhegyi and J{\^o}zsef Mandl and Michael W. H. Coughtrie and Brian Burchell},
  journal={Biochemical pharmacology},
  year={2004},
  volume={68 7},
  pages={1353-62}
}
The transport of glucuronides across the endoplasmic reticulum membrane is an important step in the overall process of biotransformation, although the mechanism remains unclear and the participating transporters are unidentified. Using a rapid filtration assay in combination with liquid chromatography-mass spectrometry, we measured the transport of a variety of beta-D-glucuronides in rat liver microsomes and investigated the substrate specificity of the participating transporter(s) by… CONTINUE READING

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