Evidence for motivational effects elicited by activation of GABA-A or dopamine receptors in the nucleus accumbens shell.

@article{Wirtshafter2010EvidenceFM,
  title={Evidence for motivational effects elicited by activation of GABA-A or dopamine receptors in the nucleus accumbens shell.},
  author={David Wirtshafter and Thomas R. Stratford},
  journal={Pharmacology, biochemistry, and behavior},
  year={2010},
  volume={96 3},
  pages={342-6}
}
Microinjections of the inhibitory GABA-A receptor agonist muscimol into the shell region of the nucleus accumbens (AcbSh) have been reported to induce large increases in food intake, but the effect of these injections on motivational processes is less clear. In the current study, bilateral injections of saline, muscimol (50ng/side) or d-amphetamine (10mug/side) were made into the AcbSh of rats trained to lever press on a progressive ratio schedule for food reward. Injections of both muscimol… CONTINUE READING

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