Corpus ID: 452853

Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.

  title={Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.},
  author={Z. Chen and L. Lash},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={285 2},
  • Z. Chen, L. Lash
  • Published 1998
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
  • The role of organic anion transporters in the mitochondrial uptake of glutathione (GSH) was investigated by assessing competition with substrates or inhibition with inhibitors of specific carriers and modulation of mitochondrial energetics. Potential artifacts in the transport methodology, including contamination of matrix space with extramitochondrial fluid, changes in matrix volume during incubations, efflux of transported GSH during sample processing, induction of the membrane permeability… CONTINUE READING
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