Corpus ID: 452853

Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.

@article{Chen1998EvidenceFM,
  title={Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.},
  author={Z. Chen and L. Lash},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={285 2},
  pages={
          608-18
        }
}
  • Z. Chen, L. Lash
  • Published 1998
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
  • The role of organic anion transporters in the mitochondrial uptake of glutathione (GSH) was investigated by assessing competition with substrates or inhibition with inhibitors of specific carriers and modulation of mitochondrial energetics. Potential artifacts in the transport methodology, including contamination of matrix space with extramitochondrial fluid, changes in matrix volume during incubations, efflux of transported GSH during sample processing, induction of the membrane permeability… CONTINUE READING
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    References

    SHOWING 1-10 OF 39 REFERENCES
    Evidence That the Rat Hepatic Mitochondrial Carrier Is Distinct from the Sinusoidal and Canalicular Transporters for Reduced Glutathione
    • 56
    • PDF
    Uptake of glutathione by renal cortical mitochondria.
    • 57
    The role of glutathione in the retention of Ca2+ by liver mitochondria.
    • 197
    High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.
    • 256
    • Highly Influential
    • PDF
    Intracellular distribution of thiols and disulfides: assay of mitochondrial glutathione transport.
    • L. Lash
    • Biology, Medicine
    • Methods in enzymology
    • 1995
    • 10
    Relationships between the NAD(P) redox state, fatty acid oxidation, and inner membrane permeability in rat liver mitochondria.
    • 57
    Status of the mitochondrial pool of glutathione in the isolated hepatocyte.
    • 390
    The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors.
    • 383
    • PDF
    Direct evidence for the role of the membrane potential in glutathione transport by renal brush-border membranes.
    • 61
    • PDF