Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.

@article{Stavinoha2004EvidenceFM,
  title={Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.},
  author={Melissa A Stavinoha and Joseph W Rayspellicy and M Faadiel Essop and Christophe Graveleau and E. Dale Abel and Mary L Hart-Sailors and Harry John Mersmann and Molly S. Bray and Martin Elliot Young},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={287 5},
  pages={E888-95}
}
The physiological role of mitochondrial thioesterase 1 (MTE1) is unknown. It was proposed that MTE1 promotes fatty acid (FA) oxidation (FAO) by acting in concert with uncoupling protein (UCP)3. We previously showed that ucp3 is a peroxisome proliferator-activated receptor-alpha (PPAR alpha)-regulated gene, allowing induction when FA availability increases. On the assumption that UCP3 and MTE1 act in partnership to increase FAO, we hypothesized that mte1 is also a PPAR alpha-regulated gene in… CONTINUE READING