Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host.

@article{Hull2000EvidenceFM,
  title={Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host.},
  author={Christina M. Hull and Ryan M. Raisner and Alexander Johnson},
  journal={Science},
  year={2000},
  volume={289 5477},
  pages={307-10}
}
Since its classification nearly 80 years ago, the human pathogen Candida albicans has been designated as an asexual yeast. In this report, we describe the construction of C. albicans strains that were subtly altered at the mating-type-like (MTL) locus, a cluster of genes that resembles the mating-type loci of other fungi. These derivatives were capable of mating after inoculation into a mammalian host. C. albicans is a diploid organism, but most of the mating products isolated from a mouse host… CONTINUE READING

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