Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study.

@article{Ernst2000EvidenceFL,
  title={Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study.},
  author={Thomas Michael Ernst and Linda Chang and Maria Leonido-Yee and Oliver Speck},
  journal={Neurology},
  year={2000},
  volume={54 6},
  pages={1344-9}
}
OBJECTIVE To determine whether proton MRS (1H MRS) can detect long-term metabolite abnormalities in abstinent methamphetamine users. BACKGROUND Methamphetamine is toxic to dopaminergic and serotonergic neurons in rodents; however, little data are available on the toxic effects of methamphetamine on the human brain. METHODS 1H MRS was performed in 26 abstinent methamphetamine abusers with a history of methamphetamine dependence (median total cumulative lifetime exposure, 3,640 g; median… CONTINUE READING
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