Evidence for lipoxygenase pathway involvement in allergic tracheal contraction.

@article{Burka1980EvidenceFL,
  title={Evidence for lipoxygenase pathway involvement in allergic tracheal contraction.},
  author={John F. Burka and Nigel A M Paterson},
  journal={Prostaglandins},
  year={1980},
  volume={19 4},
  pages={499-515}
}
Challenge of actively sensitized guinea-pig trachea in vitro led to a contraction which was enhanced by the cyclo-oxygenase inhibitors, indomethacin and sodium meclofenamate. Cyclo-oxygenase inhibitors eliminated the release of PGE-like material induced by arachidonic acid (AA), histamine, and antigen challenge. AA (10 microgram./ml.) and PGE2 (100 ng./ml.) usually relaxed the trachea, whereas in the presence of cyclo-oxygenase inhibitors a contraction occurred. Phenidone and ETYA, which also… CONTINUE READING