Evidence for linkage of restless legs syndrome to chromosome 9p

  title={Evidence for linkage of restless legs syndrome to chromosome 9p},
  author={Katja Lohmann-Hedrich and Anja Neumann and Andre Kleensang and Thora Lohnau and Hans Muhle and Ana Djarmati and Inke Regina K{\"o}nig and Peter Paul Pramstaller and Eberhard Schwinger and Patricia Kramer and Andreas Ziegler and Ulrich Stephani and Christine Klein},
  pages={686 - 694}
Background: Restless legs syndrome (RLS) is a common sensory-motor disorder characterized by paresthesias and an intense urge to move the legs with a considerable familial aggregation. To date, no gene mutation has been found, but five gene loci have been mapped in primary RLS to chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1 through 5). Patients/Methods: We identified a four-generational German RLS family with 37 family members including 15 affected cases. We performed linkage analysis using… 

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  • I. PichlerF. Marroni P. Pramstaller
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
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