Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1.

@article{Bird1982EvidenceFL,
  title={Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1.},
  author={Thomas D. Bird and J{\"u}rg Ott and Eloise R. Giblett},
  journal={American journal of human genetics},
  year={1982},
  volume={34 3},
  pages={388-94}
}
A linkage study was performed on three families with classic Charcot-Marie-Tooth (CMT) hereditary neuropathy with clinical manifestations of autosomal dominant inheritance, distal muscle weakness and atrophy, hyporeflexia, and slow motor nerve conduction velocities. Two families comprising 3 and 4 generations and a total of 23 affected persons were informative for the Duffy locus known to be on the long arm of chromosome 1. The maximum total lod score was 2.297 at recombination fraction theta… CONTINUE READING