Evidence for lidocaine-induced enzyme inactivation.

  title={Evidence for lidocaine-induced enzyme inactivation.},
  author={Bradley A. Saville and Murray R. Gray and Yun Kau Tam},
  journal={Journal of pharmaceutical sciences},
  volume={78 12},
The effects of lidocaine on hepatic enzyme activity were studied using the isolated perfused rat liver. The in vivo liver activity was examined by infusing lidocaine via the jugular vein, followed by organ isolation and drug perfusion 24 h later. The liver was studied in vitro by perfusing the organ with lidocaine until steady state was reached, then allowing the drug and metabolites to wash out of the organ, followed by a second infusion of lidocaine to probe enzyme activity. In both types of… CONTINUE READING

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