Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.

@article{Negishi2006EvidenceFL,
  title={Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.},
  author={Hideo Negishi and Yasuyuki Fujita and Hideyuki Yanai and Shinya Sakaguchi and Xinshou Ouyang and Masahiro Shinohara and Hiroshi Takayanagi and Yusuke Ohba and T. Taniguchi and Kenya Honda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 41},
  pages={15136-41}
}
The recognition of microbial components by Toll-like receptors (TLRs) initiates signal transduction pathways, which trigger the expression of a series of target genes. It has been reported that TLR signaling is enhanced by cytokines such as IFN-gamma, but the mechanisms underlying this enhancement remain unclear. The MyD88 adaptor, which is essential for signaling by many TLRs, recruits members of the IFN regulatory factor (IRF) family of transcription factors, such as IRF5 and IRF7, to evoke… CONTINUE READING
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