Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection.

@article{Harcourt2003EvidenceFL,
  title={Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection.},
  author={Gillian C Harcourt and Michaela Lucas and Andrew J. Godkin and Maria Kantzanou and Rodney E. Phillips and Paul Klenerman},
  journal={Clinical and experimental immunology},
  year={2003},
  volume={131 1},
  pages={122-9}
}
CD4+ T lymphocyte responses are thought to play a major role in control of the hepatitis C virus (HCV). Few, however, have been mapped down to the level of peptide and HLA restriction. Furthermore, the ability of such T cells to respond to viruses which differ in genotype has not been addressed in detail. In most cases of persistent infection with HCV, CD4 proliferative responses are weak or absent. From a large cohort of persistently infected patients, we identified an individual with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Hepatitis Prevention and Treatment

Lawrence M. Blattl, M J Tong
Milestones in Drug Therapy • 2004

Similar Papers

Loading similar papers…