Evidence for lack of a role of cGMP in effect of alpha-hANP on aldosterone inhibition.

@article{Matsuoka1987EvidenceFL,
  title={Evidence for lack of a role of cGMP in effect of alpha-hANP on aldosterone inhibition.},
  author={Hiroaki Matsuoka and Masao Ishii and Yasunobu Hirata and Kenichi Atarashi and Taro Sugimoto and Kenji Kangawa and Hisayuki Matsuo},
  journal={The American journal of physiology},
  year={1987},
  volume={252 5 Pt 1},
  pages={E643-7}
}
To investigate the role of guanosine 3',5'-cyclic monophosphate (cGMP) in the inhibitory effect on aldosterone production of alpha-human atrial natriuretic polypeptide (alpha-hANP) we first compared the effects of the peptide with those of sodium nitroprusside (SNP) on the production of aldosterone and cGMP in dispersed adrenal capsular cells of rats, second, examined the effects of derivatives of cGMP on the production of aldosterone, and, third, studied the influence of potassium on the… CONTINUE READING